9/4/2023 0 Comments Deep vein thrombosisTogether, acute venous and arterial thrombosis accounts for the most common causes of death in developed countries. It should only be completed in carefully selected patients or with subspecialty hematology evaluation prior. Furthermore, a decision to pursue an exhaustive hypercoagulable workup to further evaluate for inherited or acquired conditions that predispose to thrombosis is controversial. The use and duration of anticoagulation or antiplatelet therapy depend on a careful evaluation of these factors. Many factors can impact management decisions, including whether venous or arterial, acute or chronic, first or subsequent episode, family history, risk factor assessment, and hemodynamic stability. They can arise in any organ system, and their clinical presentation can vary depending on underlying comorbidities and presence (or absence) of provoking factors. As such, the diagnosis and management of thrombosis are complex. In certain clinical circumstances, patients can be at increased risk of thrombosis and bleeding simultaneously (e.g., disseminated intravascular coagulopathy-DIC, or in patients with underlying malignancy who develop a coagulopathy). When there is an imbalance with this physiologic process, there can be an increased risk of developing a thrombosis versus a coagulopathy (increased risk of bleeding). The ability of blood to flow freely in vessels relies on complex homeostasis that exists between blood cells (including platelets), plasma proteins, coagulation factors, inflammatory factors and cytokines, and the endothelial lining within the lumen of arteries and veins. DOI: 10.1111/jth.Thrombosis is the formation of a blood clot (partial or complete blockage) within blood vessels, whether venous or arterial, limiting the natural flow of blood and resulting in clinical sequela. Family history of venous thromboembolism (VTE) and risk of recurrent hospitalization for VTE: A nationwide family study in Sweden. The effects of obesity on venous thromboembolism: A review.
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